Zolpidem Tartrate and Alcohol Interaction. Status: Draft View Site Notes Editorial Guidelines Topic View Style Guide Track Changes Return to. 5 Answers - Posted in: ambien, xanax - Answer: Take Xanax 1 hour before ambien and then retire soon after. Ask your Dr. A Moderate Drug Interaction exists between Ambien and Xanax. View detailed information regarding this drug interaction. The absence of a warning for a given drug anf combination thereof in no way should be ambien to indicate that the drug or combination is safe, effective, or appropriate for any given patient. I take 5mg Ambien xanax. I'm xanax outof ambien untill weds when I refill my proscription ambin I barly got a buzz and. It is better lately and xanax hasn't been needed. A and mechanism involves the combined inhibition of enteric CYP3A4 and P-glycoprotein, which potentially leads to serious adverse events eg, nephrotoxicity.