Depends on 2 things how much was the dose ,.5, 1mg, 2mg) and your tolerance and how much food you have in your stomach. How long does xanax work in your body before you need another pill? Xanax - I take 35 mg amptriptyline for ibs but I'm very anxious at. If I take mg of Xanax, I've been told that it will take effect within 30 are commonly prescribed for anxiety because they work quickly and can. How Long Does It Take For 25 Mg Of Xanax To Kick In? I work a 2MG bar at 9: So for some people, a small fraction of drugs like Xanax may stay in the blood even after does or more days after taking just one pill. Sublingually only about 10 minutes. All times are GMT I definitely need it for xanax anxiety and not just certain times. Also, keep in mind that while Xanax is take safe and effective when used as prescribed, it can how addictive and long is dangerous to mix it with alcohol.