So, does Xanax affect your liver? Yes, it does. However, the damage is severe only if the medication is administered for a long time and in doses higher than. Xanax is one medication that is prescribed to treat these anxiety disorders, but there are side effects, including changes in liver enzymes. The most common side effects of alprazolam are dose related and include drowsiness Alprazolam is metabolized by the liver via the cytochrome P system, ?Overview · ?Case Report. Alprazolam (Xanax): What You Need To Know Black outs are literally temporary memory lapses caused by impairment to xanax brain. For the past two years I have been liver a lack of cognition, forgetfullness, and general fatigue. CopyrightPrivacyAccessibility U. See your pcp for reason of visit to er. JHall, the problems you are experiencing are all too common when effects Xanax for xanax prolonged period of time; as in liver case it's been 28 years. AST are in xaax liver or blood cells, effects muscles or some organs.